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※필독 - 12월 16일 해외연사 초청 세미나※
관리자  2011-11-25 13:49:08, 조회 : 1,350, 추천 : 78


일시 : 12월 16일 오전 10시

장소 : 인문관 소극장

연사 : Dana Carroll (Utah Univ.)


Gene Targeting분야의 세계적인 권위자이신

Utah 대학교의 Dana Carroll 교수님의 세미나가 예정되어있습니다.

많은 참석 부탁드립니다.


특히 분자세포학, 면역학 출석체크가 이뤄지므로

참석하는 학생들은 필히 세미나 전에

강연장 앞 데스크에서 출석체크를 하고 입장하기 바랍니다.



초록:
Efficient Gene Targeting with Zinc-finger Nucleases

Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene targeting tools. ZFN-induced double-strand breaks are subject to cellular DNA repair processes that lead to both targeted mutagenesis and targeted gene replacement at remarkably high frequencies. This talk will briefly review the history of ZFN development and summarize applications that have been made to genome alterations in many different organisms. Most of the work in my lab has been done with the fruit fly, Drosophila melanogaster, where we have explored mechanisms of repair of ZFN-induced breaks and attempted to optimize aspects of the gene targeting procedure. Recently we have focused our attention on properties of the donor DNA that affect the efficiency of gene replacement. Other issues that impact the utility of ZFNs will also be addressed.







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